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论文题目

Dailymorninglighttherapyisassociatedwithanincreaseinchoroidalthicknessinhealthyyoungadults

每日晨光疗法与健康年轻人脉络膜厚度增加有关

发表期刊

ScientificReports.

.8(1).ScottA.Read,EmilyC.Pieterse,DavidAlonso-Caneiro,RebekahBormann,SeentinieHong,

Chai-HoonLo,RhiannonRicher,AtifSyedLindaTran.

非学不可

摘要

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1

目的

Purpose:Toexaminetheinfluenceofa1-weekperiodofmorninglighttherapyuponchoroidalthickness.

目的:探讨晨光治疗1周对脉络膜厚度的影响。

2

方法

Methods:Twentythreehealthyyoungadultsubjectsagedbetween20to29years(mean±SDage22.2±2.2years)participatedinthisstudyandhadaseriesofchoroidalthicknessmeasurementscollectedbefore,andthenfollowinga1-weekperiodofincreaseddailylightexposure(inducedthroughthedailyuseoflighttherapyglasses).Hadarangeofsphericalequivalentrefractiveerrors(SER)rangingfrom+1.00to?5.75D(mean±SDSER?1.21±2.15D).Noparticipantsexhibitedanisometropiaof1.00Dorastigmatismof?1.50DC(mean±SDastigmaticrefractiveerror?0.26±0.44DC).Allparticipantsinthestudyhadaseriesofchoroidalthicknessmeasurementscapturedusingspectraldomainopticalcoherencetomography(SD-OCT).OcularbiometrymeasureswerealsocollectedateachsessionusingtheLenstarLS(HaagStreitAG,Koeniz,Switzerland)opticalbiometer.Inordertoexamineeachparticipant’shabitualdailylightexposureandsleeppatternsthroughoutthestudy,eachsubjectworeawrist-watchactigraphydevice(Actiwatch2,PhillipsRespironics)ontheirnon-dominantwrist24-hoursadayfora14-dayperiod.

方法:23名年龄在20至29岁(平均年龄22.2±2.2岁)的健康青年受试者参加了本研究,在每天增加光照(通过每天使用光疗眼镜诱导)1周后,收集了一系列脉络膜厚度测量数据。所有受试者最佳矫正视力为logMAR0.00或更好,球镜(SER)范围为+1.00至-5.75D(平均值±SDSER-1.21±2.15D)。无受试者屈光参差1.00d或散光1.50dc(平均值±SD散光屈光误差-0.26±0.44dc)。使用光谱域光学相干断层扫描(SD-OCT)进行了一系列脉络膜厚度测量。使用LenstarLS(HaagStreitAG,Koeniz,Switzerland)光学生物测量仪收集眼部生物测量值。为了在整个研究过程中检查每个参与者的习惯性每日光照和睡眠模式,每个受试者在他们的非支配性手腕上24小时佩戴腕表活动记录装置(Actiwatch2,PhillipsRespironics),持续14天。

3

结果

Results:witha1-weekperiodofmorninglighttherapyfoundtoresultinasmallbutstatisticallysignifcantincreaseinchoroidalthickness(meanincrease+5.4±10.3μm;95%CI+0.8to+9.9μm;p=0.02).Asignifcantoveralldiferenceinthicknessacrossthemacularregionwasfound(p0.),withthethicknessofthenasalregionfoundtobesignifcantlythinnerthanallotherconsideredregions.Similartothevariationsinthesubfovealchoroid,asignifcantefectoftimeofday(p0.)wasobservedinthemacularchoroid.ferencesinhourlylightexposurebetweenthebaselineandlighttherapyperiodsatanyothertimesoftheday.Theaveragedailywaketimewasfoundtobesignificantlyearlier(meandifference14±25minutes;95%CI:3to26minutes)duringthelight-therapyperiod(p=0.02)

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